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Clinical evidence

Our evidence

Every figure on this site is reviewed by our prescriber and rechecked every 12 months.

Established

Several blinded randomised trials with 12 to 24 month follow up.

Over0%
1

In a randomised study of 225 adults, more than 60% still had improved lip fullness at 1 year.

Product
Juvederm Volbella
Study size
225 adults
Time point
1 year

Results vary from person to person.

Established

Several blinded randomised trials with 12 to 24 month follow up.

0%
2

In a study of 235 people treated for cheek volume loss, 79% rated their cheeks as improved 2 years later.

Product
Juvederm Voluma
Study size
235 people
Time point
2 years

Results vary from person to person.

Established

Several blinded randomised trials with 12 to 24 month follow up.

Treated69%
Untreated38%
3

In a randomised study of 206 adults, 69% had improved jawline definition at 6 months, compared with 38% untreated.

Product
Juvederm Volux
Study size
206 adults
Time point
6 months

Results vary from person to person.

Emerging

Small studies, longest verified follow up 16 weeks.

016 weeks
4

In a study of 64 women given 2 treatments 4 weeks apart, improvements were still measurable at 16 weeks.

Product
Profhilo
Study size
64 women
Time point
16 weeks

Results vary from person to person.

Supported

Controlled studies with blinded assessors, but small numbers.

Over0%
5

In a study of 30 people given 3 sessions, a blinded assessor judged skin quality improved in over 80%, with follow up to 36 weeks.

Product
Restylane Skin Boosters
Study size
30 people
Time point
36 weeks

Results vary from person to person.

Emerging

Small or observational studies; the evidence is still developing.

0%
6

In a real world survey, 48% of facial treatments were rated much or very much improved 3 months after a course of 3 sessions.

Product
Newest
Study size
218 questionnaires from 12 clinics
Time point
3 months after the last of 3 sessions
Design
real world post market survey

Results vary from person to person.

Emerging

Small or observational studies; the evidence is still developing.

010203
7
Product
Plinest Eye
Study size
61 people
Time point
1 and 3 months after the course
Design
Observational study of 61 people using Plinest Eye, assessed at 1 and 3 months

Results vary from person to person.

References

  1. Geronemus et al., Dermatologic Surgery, 2017.
  2. Few et al., Aesthetic Surgery Journal, 2015.
  3. Rivkin et al., Aesthetic Surgery Journal, 2024.
  4. Sparavigna and Tenconi, Clinical, Cosmetic and Investigational Dermatology, 2016.
  5. Streker et al., Journal of Drugs in Dermatology, 2013.
  6. Savoia et al., Cosmetics, 2026.
  7. Amado et al., Clinical, Cosmetic and Investigational Dermatology, 2026.

Evidence ratings

dermal fillersEstablished

Several blinded randomised trials with 12 to 24 month follow up.

lip fillerEstablished

Several blinded randomised trials with 12 to 24 month follow up.

restylane skin boostersSupported

Controlled studies with blinded assessors, but small numbers.

profhiloEmerging

Small studies, longest verified follow up 16 weeks.

polynucleotidesEmerging

Small or observational studies; the evidence is still developing.